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Research

We did the research

Red Thyme

General gut health

The Potential Gastrointestinal Health Benefits of Thymus Vulgaris Essential Oil: A Review

Antibacterial Activity of Thyme and Lavender Essential Oils

The Potential Gastrointestinal Health Benefits of Thymus Vulgaris Essential Oil: A Review

A Focused Insight into Thyme: Biological, Chemical, and Therapeutic Properties of an Indigenous Mediterranean Herb

Thymol and Thyme Essential Oil—New Insights into Selected Therapeutic Applications

Specific gut condition: SIBO

Select Herbals Proposed as Beneficial in the Eradication of Small Intestinal Bacterial Overgrowth

Specific gut condition: IBS

Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome

Oregano

Specific gut condition: SIBO

Essential Oils of Oregano: Biological Activity beyond Their Antimicrobial Properties

Susceptibility and intrinsic tolerance of Pseudomonas aeruginosa to selected plant volatile compounds

The Natural Antimicrobial Carvacrol Inhibits Campylobacter jejuni Motility and Infection of Epithelial Cells

The antibacterial mechanism of carvacrol and thymol against Escherichia coli

Specific gut condition: IBS

Herbs and Spices in the Treatment of Functional Gastrointestinal Disorders: A Review of Clinical Trials

Sage leaf

General gut health

Chemistry, Pharmacology, and Medicinal Property of Sage (Salvia) to Prevent and Cure Illnesses such as Obesity, Diabetes, Depression, Dementia, Lupus, Autism, Heart Disease, and Cancer

Medicinal Plant Leaf Extract From Sage and Lemon Verbena Promotes Intestinal Immunity and Barrier Function in Gilthead Seabream (Sparus aurata)

Specific gut condition: IBS

Herbal medicines for the management of irritable bowel syndrome: A comprehensive review

The Treatment of Irritable Bowel Syndrome

Complementary and Alternative Medicine and Mind–Body Therapies for Treatment of Irritable Bowel Syndrome in Women

Irritable Bowel Syndrome

Lemon balm leaf

General gut health

Chemical composition and in vitro antimicrobial activity of essential oil of Melissa officinalis L. from Romania

Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis L. on Intestinal Motility: An Ex Vivo Study

Specific gut condition: SIBO

Herbal Therapies in Functional Gastrointestinal Disorders: A Narrative Review and Clinical Implication

Investigation of the Antimicrobial activity of essential oils of culinary and medicinal herbs and spices against selected gastrointestinal pathogens

Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome

Specific gut condition: IBS

The Protective Effect of Melissa officinalis L. in Visceral Hypersensitivity in Rat Using 2 Models of Acid-induced Colitis and Stress-induced Irritable Bowel Syndrome: A Possible Role of Nitric Oxide Pathway

Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial

Herbs and Spices in the Treatment of Functional Gastrointestinal Disorders: A Review of Clinical Trials

Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome

Combining Herbs in a Formula for Irritable Bowel Syndrome

Peppermint oil

General gut health

Peppermint oil effects on the gut microbiome in children with functional abdominal pain

Specific gut condition: SIBO

Herbal Medicines for Gastrointestinal Disorders in Children and Adolescents: A Systematic Review

The treatment of small intestinal bacterial overgrowth with enteric-coated peppermint oil: A case report

Specific gut condition: IBS

The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data

Review article: The physiologic effects and safety of Peppermint Oil and its efficacy in irritable bowel syndrome and other functional disorders

Peppermint Oil for the Treatment of Irritable Bowel Syndrome: Optimizing Therapeutic Strategies Using Targeted Delivery (PERSUADE)

Berberine

General gut health

Effects of Berberine on the Gastrointestinal Microbiota

Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)

Interactions between gut microbiota and berberine, a necessary procedure to understand the mechanisms of berberine

Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study

Berberine and probiotics supplementation decreases post-meal lipid spike in Type II diabetes patients – 12-week RCT

Specific gut condition: SIBO

Eradication of small intestinal bacterial overgrowth in irritable bowel syndrome using herbal therapy: A case report

Specific gut condition: IBS

Berberine prevents stress-induced gut inflammation and visceral hypersensitivity and reduces intestinal motility in rats

A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome

Therapeutic Effects of Berberine Hydrochloride on Stress-Induced Diarrhea-Predominant Irritable Bowel Syndrome Rats by Inhibiting Neurotransmission in Colonic Smooth Muscle

Berberine Improves Symptoms of Irritable Bowel Syndrome

Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner

Effect of berberine on irritable bowel syndrome: A symptom-based review

Chinese Rhubarb root and rhizome

General gut health

A Systematic Review of Rhubarb (a Traditional Chinese Medicine) Used for the Treatment of Experimental Sepsis

Rheum Officinale

Potential Health Benefits of Rhubarb

Specific gut condition: SIBO

Proceedings of the 2017 2nd International Conference on Materials Science, Machinery and Energy Engineering (MSMEE 2017)

Specific gut condition: IBS

Management of Irritable Bowel Syndrome (IBS) in Adults: Conventional and Complementary/Alternative Approaches

Advances in bio-active constituents, pharmacology and clinical applications of rhubarb

Elucidating dosage-effect relationship of different efficacy of rhubarb in constipation model rats by factor analysis

The diarrhoeogenic and antidiarrhoeal bidirectional effects of rhubarb and its potential mechanism

Indian Barberry root extract

General gut health

A quick overview on some aspects of endocrinological and therapeutic effects of Berberis vulgaris L.

Effects of different forms of barberry root(Berberis vulgaris) on growth performance, muscle fatty acids profile, whole-body composition, and digestive enzymes of rainbow trout (Oncorhynchusmykiss)

Anti-Inflammatory and Immunomodulatory Effects of Barberry (Berberis vulgaris) and Its Main Compounds

Specific gut condition: IBS

Irritable bowel syndrome and diet

Herbal medicines for the management of irritable bowel syndrome: A comprehensive review

Chinese Licorice root

General gut health

Traditional Chinese medicine, liver fibrosis, intestinal flora: is there any connection?—a narrative review

An “essential herbal medicine”—licorice: A review of phytochemicals and its effects in combination preparations

Specific gut condition: SIBO

Chinese herbal medicine for the treatment of small intestinal bacterial overgrowth (SIBO)

Traditional Chinese Medicine and Gut Microbiome: Their Respective and Concert Effects on Healthcare

Alternative Treatment Approaches to Small Intestinal Bacterial Overgrowth: A Systematic Review

Specific gut condition: IBS

Treatment of Irritable Bowel Syndrome With Chinese Herbal Medicine – A Randomized Controlled Trial

Pharmacological treatments of Chinese herbal medicine for irritable bowel syndrome in adults: A network meta-analysis of randomized controlled trials

Chinese herbal medicine versus probiotics for irritable bowel syndrome: A systematic review and meta-analysis of randomized controlled trials

An Overview of Systematic Reviews of Herbal Medicine for Irritable Bowel Syndrome

Chinese Skullcap root

General gut health

Scutellaria baicalensis

Skullcap (Scutellaria baicalensis) Extract and Its Active Compound, Wogonin, Inhibit Ovalbumin-Induced Th2-Mediated Response

Anti-inflammatory effect of wogonin on allergic responses in ovalbumin-induced allergic rhinitis in the mouse

Anti-Inflammatory and Immunomodulatory Effects of Barberry (Berberis vulgaris) and Its Main Compounds

Specific gut condition: SIBO

Chinese herbal medicine for the treatment of small intestinal bacterial overgrowth (SIBO)

Specific gut condition: IBS

The Herbal Medicine Scutellaria-Coptis Alleviates Intestinal Mucosal Barrier Damage in Diabetic Rats by Inhibiting Inflammation and Modulating the Gut Microbiota

Treatment of irritable bowel syndrome in China: A review

Chinese Herbal Medicine for Irritable Bowel Syndrome: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials

Coptis root and rhizome extract

General gut health

Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

Coptidis rhizoma and its main bioactive components: recent advances in chemical investigation, quality evaluation and pharmacological activity

Specific gut condition: SIBO

The Herbal Medicine Scutellaria-Coptis Alleviates Intestinal Mucosal Barrier Damage in Diabetic Rats by Inhibiting Inflammation and Modulating the Gut Microbiota

Specific gut condition: IBS

Tracking evidences of Coptis chinensis for the treatment of inflammatory bowel disease from pharmacological, pharmacokinetic to clinical studies

Antibacterial activities of Coptis chinensis and Glycyrrhiza glabra against seven bacteria associated with human gastrointestinal infections

Ginger rhizome

General gut health

Herbs and Spices in the Treatment of Functional Gastrointestinal Disorders: A Review of Clinical Trials

Ginger in gastrointestinal disorders: A systematic review of clinical trials

Gut Microbiota Variation With Short-Term Intake of Ginger Juice on Human Health

Ginger rhizomes (Zingiber officinale): A spice with multiple health beneficial potentials

Specific gut condition: SIBO

Pharmacological Basis for the Medicinal Use of Ginger in Gastrointestinal Disorders

Specific gut condition: IBS

Is ginger effective for the treatment of Irritable Bowel Syndrome? A double blind randomized trials

Is ginger effective for the treatment of Irritable Bowel Syndrome? A double blind randomized controlled pilot trial

Ginger relieves intestinal hypersensitivity of diarrhea predominant irritable bowel syndrome by inhibiting proinflammatory reaction

Dill Seed

General gut health

The Study of Anti-Inflammatory Activity of Oil-Based Dill (Anethum graveolens L.) Extract Used Topically in Formalin-Induced Inflammation Male Rat Paw

Specific gut condition: SIBO

Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome

Select Herbals Proposed as Beneficial in the Eradication of Small Intestinal Bacterial Overgrowth

Specific gut condition: IBS

Combining Herbs in a Formula for Irritable Bowel Syndrome

Efficacy and Safety of a Novel Herbal Medicine in the Treatment of Irritable Bowel Syndrome: A Randomized Double-Blinded Clinical Trial

Herbal medicines for the management of irritable bowel syndrome: A comprehensive review

Zinc

General gut health

Zinc and gastrointestinal disease

Zinc and its importance for human health: An integrative review

Effects of Dietary Zinc Sources on Growth Performance and Gut Health of Weaned Piglets

Specific gut condition: SIBO

Chronic Dietary Zinc Deficiency Alters Gut Microbiota Composition and Function

Effects of Iron and Zinc Biofortified Foods on Gut Microbiota In Vivo (Gallus gallus): A Systematic Review

Small Intestinal Bacterial Overgrowth is Common in Chronic Pancreatitis (CP) and Associates with Diabetes, CP Severity, Low Zinc Levels and Opiate Use

Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues

Specific gut condition: IBS

P0339 – Nutritional Deficiencies in Irritable Bowel Syndrome: A North American Population-Based Study

Nutritional status in irritable bowel syndrome: A North American population‐based study

Correlation Between Zinc Nutritional Status with Serum Zonulin and Gastrointestinal Symptoms in Diarrhea-Predominant Irritable Bowel Syndrome: A Case-Control Study

Zinc Deficiency and Intestinal Permeability in the Context of Rational Diagnostic and Drug Development for Diarrhea-Predominant Irritable Bowel Syndrome

The potential impact of nutritional intake on symptoms severity in patients with comorbid migraine and irritable bowel syndrome

Glutamine

General gut health

L-Glutamine Supplementation Improves the Benefits of Combined-Exercise Training on Oral Redox Balance and Inflammatory Status in Elderly Individuals

Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

The role of glutamine in supporting gut health and neuropsychiatric factors

Specific gut condition: SIBO

The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review

Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions

Specific gut condition: IBS

Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in Irritable Bowel Syndrome Management

Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome

Glutamine for the Treatment of Patients With Irritable Bowel Syndrome (AT005291)

Clinical effects and safety of Compound Glutamine Entersoluble Capsules for diarrhea-predominant irritable bowel syndrome: A systematic review and meta-analysis

DGL Licorice

General gut health

Glycyrrhiza glabra (Licorice)

Glycyrrhiza Glabra Root

Prevention of symptoms of gastric irritation (GERD) using two herbal formulas: An observational study

Specific gut condition: SIBO

Prebiotic Potential of Herbal Medicines Used in Digestive Health and Disease

Specific gut condition: IBS

Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study

An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study

Marshmallow root

General gut health

Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon

Specific gut condition: SIBO

Aqueous extracts and polysaccharides from Marshmallow roots (Althea officinalis L.): Cellular internalisation and stimulation of cell physiology of human epithelial cells in vitro

Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders

Eradication of small intestinal bacterial overgrowth in irritable bowel syndrome using herbal therapy: A case report

Specific gut condition: IBS

Herbal medicines for the management of irritable bowel syndrome: A comprehensive review

Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study

Quercetin

General gut health

Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

Dietary Quercetin Increases Colonic Microbial Diversity and Attenuates Colitis Severity in Citrobacter rodentium-Infected Mice

Dietary Quercetin Supplementation Attenuates Diarrhea and Intestinal Damage by Regulating Gut Microbiota in Weanling Piglets

Specific gut condition: SIBO

Dietary Quercetin Increases Colonic Microbial Diversity and Attenuates Colitis Severity in Citrobacter rodentium-Infected Mice

Alternative Treatment Approaches to Small Intestinal Bacterial Overgrowth: A Systematic Review

Specific gut condition: IBS

Natural polyphenols for the prevention of irritable bowel syndrome: molecular mechanisms and targets; a comprehensive review

Quercetin Attenuates Visceral Hypersensitivity and 5-Hydroxytryptamine Availability in Postinflammatory Irritable Bowel Syndrome Rats: Role of Enterochromaffin Cells in the Colon

Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

Support beneficial bacteria

Here is the list of studies that support beneficial bacteria:

A Systematic Review of Rhubarb (a Traditional Chinese Medicine) Used for the Treatment of Experimental Sepsis

Rheum Officinale

Gut Microbial Diversity in Rat Model Induced by Rhubarb

Dietary Quercetin Increases Colonic Microbial Diversity and Attenuates Colitis Severity in Citrobacter rodentium-Infected Mice

Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

Effects of Berberine on the Gastrointestinal Microbiota

Leaf extract of Azadirachta indica (neem): a potential antibiofilm agent for Pseudomonas aeruginosa

Effect of aqueous extract from Neem (Azadirachta indica A. Juss) on hydrophobicity, biofilm formation and adhesion in composite resin by Candida albicans

Neem (Azadirachta indica): Prehistory to contemporary medicinal uses to humankind

Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment

Medicinal properties of neem leaves: a review

The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review

Improvements of immune genes and intestinal microbiota composition of turbot (Scophthalmus maximus) with dietary oregano oil and probiotics

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DISCLAIMER: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. The views and advice expressed by FixBIOME® are not meant as a substitute for professional medical advice. Please always consult a health care professional if you are taking any medications or have any medical condition before taking this or any dietary supplement. Individual results may vary.

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